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Chemical Name: 7-hydroxy-6-methoxy-3-((2-oxo-2H-chromen-7-yl)oxy)-2H-chromen-2-one
InChiKey: QIAVTDQTRFYXSD-WLHGVMLRSA-N
CAS Number: 1207456-01-6
It prevents Smad1
AN-2728 - CAS# 906673-24-3 Catalog No.:M10493-2 Chemical Name: 7-hydroxy-6-methoxy-3-((2-oxo-2H-chromen-7-yl)oxy)-2H-chromen-2-oneCrisaborole, also known as AN 2728, is a topically administered, boron containing, anti inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL 12, IL 23 and other cytokines. At the time of publication, three phase Ib clinical trials, a IIa trial and a IIb trial of AN 2728 in patients with psoriasis had been completed; the compound was also undergoing phase II development for atopic dermatitis, but no data
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