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LP-261 - CAS# 915412-67-8 Size:2mg solid 121345-64-0

SKU: 86791637472

4.4
USD120.00 USD167.00

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Description

121345-64-0

(R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121

Smiles: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

The drug was developed by Valeant Pharmaceuticals and GlaxoSmithKline

LP-261 - CAS# 915412-67-8 Size:2mg solid 121345-64-0LP 261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2 M arrest. Screening in the NCI60 cancer cell lines resulted in a mean GI50 of approximately 100 nM. LP 261 is a very potent inhibitor of angiogenesis, preventing microvessel outgrowth in the rat aortic ring assay and HUVEC cell proliferation at nanomolar concentrations. Complete inhibition of tumor growth was achieved in the PC3 xenograft

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